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Michigan Postdoctoral Pioneer Program, 2021

Collaborative PIs


Yatrik Shah, Ph.D.

University of Michigan
Department of Molecular and Integrative Physiology
Department of Internal Medicine, Division of Gastroenterology
Rogel Cancer Center

Co - Mentor

Costas A. Lyssiotis, Ph.D.

Assistant Professor, Molecular & Integrative Physiology
Assistant Professor, Internal Medicine, Division of Gastroenterology
Member, Rogel Cancer Center



Metabolic Reprogramming in the Tumor Microenvironment Supports Cancer Growth and Immune Evasion

Solid tumors are pseudo-organs comprised of a heterogenous population of malignant cells embedded in a complex stroma. This is known as the tumor microenvironment and consists of blood vessels, immune cells, fibroblasts, and extracellular matrix. The tumor microenvironment is often hypoxic, nutrient scarce, and immune rich, and it can act to both constrain and promote tumor growth. Accordingly, the malignant cells rewire metabolic programs to support growth, progression, and immune evasion. The Shah and Lyssiotis lab are interested in understanding how hetero-cellular communication between the microenvironment and cancer cells enables nutrient acquisition, metabolism, redox demands and immune cell alterations for tumor progression.